Contributor: Gordon K. Klintworth
Good syndrome (immunodeficiency with thymoma) consists of a thymoma, hypogammaglobulinemia. a reversal in the CD4/CD8 ratio and low or absent B-lymphocytes. This immunodeficiency state is a combined B-cell and T-cell deficiency and it usually occurs in adults. It is named in honor of the American Pediatrician Robert Alan Good (1922- ). Affected individuals have an increased susceptibility to bacterial infection with unencapsulated bacteria and to an opportunistic infection by viruses [viral infection] and fungi [fungal infection]. A handful of patients with this syndrome have been reported to develop cytomegalovirus retinitis [retinitis - cytomegalovirus].