Contributor: Gordon K. Klintworth
Niacin maculopathy (nicotinic acid maculopathy) is a maculopathy that follows the ingestion of high doses of niacin (>3.0 g/day) in some individuals. The maculopathy in affected persons is associated with decreased visual acuity and metamorphopsia. OCT demonstrates cystoid spaces in the outer plexiform layer and inner nuclear layer of the macula, but fluorescein angiography does not reveal any extravascular  leakage of fluorescein. The cystoid spaces resolve after stopping the intake of niacin. A similar maculopathy has been documented in persons receiving docetaxel.