Contributor: Gordon K. Klintworth
In the United States and Europe ovarian cancer is the leading cause of death from gynecologic malignant neoplasms. In the United States alone ~23,300 new cases of carcinoma of the ovary occur annually. Early symptoms are not a feature of  these tumors and a high mortality has been ascribed to the usual late diagnosis. Aside from spreading locally ovarian tumors spread to distant sites by the blood spread and they they sometimes metastastize to to the uvea, eyelid and orbit [carcinoma - metastatic]. Most cases of  bilateral diffuse uveal melanocytic proliferation  cases have been associated with an ovarian carcinoma.