Contributor: Gordon K. Klintworth
Lymphedema-districhiasis is a special rare form of lymphedema. It has an autosomal dominant mode of inheritance and is characterized by congenital districhiasis that irritate the cornea. The condition has variable expressivity and penetrance and the responsible gene has been mapped to human chromosome 16 (16q24.3). The districhiasis is present at birth, but the lymphedema does not appear until puberty of later. Associated abnormalities include congenital heart disease, vertebral anomalies, extradural cysts, ptosis and cleft palate.