Contributor: Gordon K. Klintworth
Tamoxifen retinopathy is a disorder of the retina caused by the drug tamoxifen. The retinopathy is characterized clinically by the presence of small white refractile deposits in the retina in association with a variable amount of pigmentation. The posterior retina and particularly the perimacular areinvolved. Macular edema [edema - macula] is usually also present and the cornea may contain white whorl-like subepithelial deposits. A histopathologic examination of one case showed lesions that seemed to be products of axonal degeneration limited to both the nerve fiber layer and inner plexiform layer of the retina.