Contributor: Gordon K. Klintworth
Xanthogranulomas occur at all ages and are associated with chronic inflammation. This tissue reaction is not specific for a particular disease and can occur under numerous circumstances. One specific type is the juvenile xanthogranuloma. Other conditions that can have xanthogranulomas include necrobiotic xanthogranuloma with paraproteinemia, Langerhans cell granulomatosis of  the Hand-Schüller-Christian type [Hand-Schüller-Christian disease], fibrous histiocytoma, xanthoma disseminatum, tuberous xanthoma [xanthoma - tuberous], and tendinous xanthomas [xanthoma - tendinous]. Xanthogranulomas can occur in the orbit, gallbladder [xanthogranulomatous cholecystitis], and kidney [xanthogranulomatous pyelonephritis] for reasons that are not obvious.