Contributor: Gordon K. Klintworth.
Juvenile open angle glaucoma (familial autosomal dominant glaucoma, primary open angle juvenile onset glaucoma) is an unusual type of primary open angle glaucoma [glaucoma - primary open angle] of juvenile onset (mean age 11.5-18 years) with an autosomal dominant mode of inheritance. Elevated intraocular pressure often becomes apparent by < 30 years age. The cornea is of normal size and the anterior chamber angle is unremarkable on gonioscopy. The glaucoma usually responds poorly to anti-glaucoma medications, and filtering surgery is necessary to control the intraocular pressure. An inherited predisposition is present and some cases are caused by mutations in the MYOC gene. Sometimes MYOC interacts with CYP1B1 through a digenic mechanism in causing juvenile open angle glaucoma.