Disease
Calcific band keratopathy
Overview
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Contributor: Gordon K. Klintworth
Calcific band keratopathy is a common keratopathy characterized by an opacification of the superficial cornea within the interpalpebral fissure due to a deposition of calcium phosphate in Bowman layer and the superficial corneal stroma. This form of corneal calcification [calcification - cornea] may occur at any age and has been observed at birth. In its mildest form Bowman layer has a delicate basophilic stippling, but at an advanced stage the entire thickness of this structure is affected. 
Calcific band keratopathy usually accompanies other ocular disorders, particularly chronic uveitis [uveitis - chronic], chronic glaucoma [glaucoma - chronic], and phthisis bulbi. It may follow chemical injuries and has been described as an occupational hazard of hatters. In the absence of an underlying corneal disease, calcific band keratopathy may complicate hypercalcemia as in hyperparathyroidism, an excessive ingestion of vitamin D [hypervitaminosis D], sarcoidosis, Fanconi syndrome, the milk-alkali syndrome, and hypophosphatasia.  Calcific band keratopathy occurs in children with Still disease but rarely with other types of juvenile uveitis [uveitis - juvenile]. Calcific band keratopathy has been observed in several distinct genetically determined disorders including Norrie disease, Hallerman-Doering syndromehypophosphatasia, and familial subepithelial corneal amyloidosis.